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Use Warning/Check. Ethinyl estradiol may possibly inhibit the clearance of benzodiazepines that undertake oxidation, thereby escalating serum concentrations of concomitantly administered benzodiazepines.bosentan will lower the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Benzodiazepine cu